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Covid: Viruses and Vaccines


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Clif's retweet.

 

 

Yes, many might not have COVID but, were they vaccinated? Whatever the case is, this is scary.

 

It's also not a staffing shortage due to COVID mandates (though the article does say they are hiring basically unskilled workers), because the hospital talked about in the article, Sparrow has not joined the growing list of healthcare organizations in Michigan to mandate the vaccine.

 

Excerpts from the rather long NPR article.

 

ERs are now swamped with seriously ill patients — but many don't even have COVID

Quote

Inside the emergency department at Sparrow Hospital in Lansing, Mich., staff members are struggling to care for patients who are showing up much sicker than they've ever seen.

 

Tiffani Dusang, the emergency room's nursing director, practically vibrates with pent-up anxiety, looking at all the patients lying on a long line of stretchers pushed up against the beige walls of the hospital's hallways. "It's hard to watch," she says in her warm Texan twang.

 

But there's nothing she can do. The ER's 72 rooms are already filled.

 

"I always feel very, very bad when I walk down the hallway and see that people are in pain or needing to sleep or needing quiet. But they have to be in the hallway with, as you can see, 10 or 15 people walking by every minute."

 

It's a stark contrast to where this emergency department — and thousands others — were at the start of the coronavirus pandemic. Except for initial hot spots like New York City, many ERs across the U.S. were often eerily empty in the spring of 2020. Terrified of contracting COVID-19, people who were sick with other things did their best to stay away from hospitals. Visits to emergency departments dropped to half their normal levels, according to the Epic Health Research Network, and didn't fully rebound until the summer of 2021. ...

 

...This isn't just happening at Sparrow.

 

"We are hearing from members in every part of the country," says Dr. Lisa Moreno, president of the American Academy of Emergency Medicine (AAEM). "The Midwest, the South, the Northeast, the West ... they are seeing this exact same phenomenon." ...

 

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A MDPI Journal Publication

 

SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro

... Academic Editor: Oliver Schildgen

Viruses 2021, 13(10), 2056; https://doi.org/10.3390/v13102056

Received: 20 August 2021 / Revised: 8 September 2021 / Accepted: 8 October 2021 / Published: 13 October 2021 ...

 

Abstract

 

Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role in fighting against SARS–CoV–2 infection and directly influences the clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID–19 exhibit delayed and weak adaptive immune responses; however, the mechanism by which SARS–CoV–2 impedes adaptive immunity remains unclear. Here, by using an in vitro cell line, we report that the SARS–CoV–2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines. ...

 

...4. Discussion

 

Our findings provide evidence of the spike protein hijacking the DNA damage repair machinery and adaptive immune machinery in vitro. We propose a potential mechanism by which spike proteins may impair adaptive immunity by inhibiting DNA damage repair. Although no evidence has been published that SARS–CoV–2 can infect thymocytes or bone marrow lymphoid cells, our in vitro V(D)J reporter assay shows that the spike protein intensely impeded V(D)J recombination. Consistent with our results, clinical observations also show that the risk of severe illness or death with COVID–19 increases with age, especially older adults who are at the highest risk [22]. This may be because SARS–CoV–2 spike proteins can weaken the DNA repair system of older people and consequently impede V(D)J recombination and adaptive immunity. In contrast, our data provide valuable details on the involvement of spike protein subunits in DNA damage repair, indicating that full–length spike–based vaccines may inhibit the recombination of V(D)J in B cells, which is also consistent with a recent study that a full–length spike–based vaccine induced lower antibody titers compared to the RBD–based vaccine [28]. This suggests that the use of antigenic epitopes of the spike as a SARS–CoV–2 vaccine might be safer and more efficacious than the full–length spike. Taken together, we identified one of the potentially important mechanisms of SARS–CoV–2 suppression of the host adaptive immune machinery. Furthermore, our findings also imply a potential side effect of the full–length spike–based vaccine. This work will improve the understanding of COVID–19 pathogenesis and provide new strategies for designing more efficient and safer vaccines. ...

 

bullet point 4 emphasis, mine.

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  • 2 weeks later...
  • 3 weeks later...

There is so much confusion in everything these days. Even doctors not understanding what a string of words put together says or means. Which then thusly provides for the propagation of misinformation.

 

Case in point:

https://twitter.com/PierreKory/status/1467197002673008649

 

Note the, 'placebo outperforms drug' comment above.

 

From the article:

FDA Staff: Mediocre Efficacy for Merck's Pill in High-Risk COVID

... In the full analysis, 710 patients received the drug at that dose. The rate of all-cause hospitalization or death was 6.8% in the intervention group and 9.7% in the placebo group, for a relative risk reduction of 30% (95% CI 1%-51%), the agency said in an addendum to the current analysis. ...

 

I mean, I'm just some dumb keyboard jockey but...  I'm pretty sure the above, from the article, means that the rate of hospitalizations for those taking the placebo was higher. This guy is an MD? Yikes.

 

The portion of the article that would have caught my attention is thus:

... They also mentioned the potential risk of viral mutation associated with use of the drug, specifically "an increased rate of amino acid changes in the SARS-CoV-2 spike protein." However, FDA staff said these mutations did not appear to be associated with clinical outcomes, such as hospitalization or death. They added that while there may not be individual patient changes, there may be implications for population health if the spike protein evolves. ...

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https://twitter.com/clif_high/status/1470785077823082503

 

:facepalm:

I'm pretty sure that's not what the article says, at all. That is Clif's narrative.

 

Additionally, why link to an article that is behind a paywall that most will not read? Because it enables the push of said narrative?

 

Here is an article that appears like it maybe almost the same (can't be sure because I can't see behind the paywall).

Expert reveals who is spreading Omicron variant of Covid-19

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Clif reTweeted this tweet about an article that is behind a paywall for the most part. With headlines today that say something of which the article contains almost nothing thereof, can we be confident that this is something or does the headline simply fit Clif's narrative and therefore the reTweet? I'ma go with the latter.

 

https://twitter.com/clif_high/status/1483127415031300096

 

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